منابع مشابه
A Mutant Allele Encoding DNA Binding–Deficient FoxO1 Differentially Regulates Hepatic Glucose and Lipid Metabolism
Insulin signaling in the liver blunts glucose production and stimulates triglyceride biosynthesis. FoxO1 is required for cAMP induction of hepatic glucose production and is permissive for the effect of insulin to suppress this process. Moreover, FoxO1 ablation increases lipogenesis. In this study, we investigated the pleiotropic actions of FoxO1 on glucose and lipid metabolism. To this end, we ...
متن کاملDual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.
Hepatic insulin resistance affects both carbohydrate and lipid metabolism. It has been proposed that insulin controls these 2 metabolic branches through distinct signaling pathways. FoxO transcription factors are considered effectors of the pathway regulating hepatic glucose production. Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver result...
متن کاملSIRT7 and hepatic lipid metabolism
The mammalian sirtuin family, consisting of NAD+-dependent class III histone/protein deacetylases, has 7 members (Greiss and Gartner, 2009). The physiological activities and pathological associations of sirtuins have been subjects of intense interest, as these are key regulators of metabolic processes that often impinge on health, aging and lifespan (Chalkiadaki and Guarente, 2012; Houtkooper e...
متن کاملLipid absorption and hepatic metabolism in ruminants
Les matikres grasses sont ajoutCes aux rations des ruminants pour ameliorer l’efficacite d’utilisation de 1’Cnergie B des fins de production. L’intestin gr&le des ruminants posskde une forte capacitC d’absorption des acides gras alimentaires saturCs par l’action des hydrogenases bactkriennes du rumen. La synthkse et la secretion des lipoproteines riches en triacylglycerols (chylomicrons, VLDL) ...
متن کاملER stress and hepatic lipid metabolism
The endoplasmic reticulum (ER) is an important player in regulating protein synthesis and lipid metabolism. Perturbation of ER homeostasis, referred as "ER stress," has been linked to numerous pathological conditions, such as inflammation, cardiovascular diseases, and metabolic disorders. The liver plays a central role in regulating nutrient and lipid metabolism. Accumulating evidence implicate...
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ژورنال
عنوان ژورنال: Current Opinion in Lipidology
سال: 2009
ISSN: 0957-9672
DOI: 10.1097/mol.0b013e32832b3f4c